Tag Archives: Citalopram

FDA limits Celexa (Citalopram) usage to doses under 40mg per day

I’d like to discuss strategies to ensure patient safety in the inpatient environment following the Food and Drug Administrations’ recently announced dosage limitations for Celexa.

As you may know, earlier this week the FDA, through a Drug Safety Communication, issued a stark warning that the popular anti-depressant should not be used at doses above 40mg per day.  The concern is that changes in the electrical activity of the heart, seen as prolongation of the QT interval of the electrocardiogram, or ECG can lead to an abnormal heart rhythm, including Torsade de Pointes, which can be fatal. Patients at particular risk for developing prolongation of the QT interval include those with underlying heart conditions and those who are predisposed to low levels of potassium and magnesium in the blood.